The content of the Home screen banner should not affect the use of the remote control.. I didn't have any problems with the remote control when the Home screen banner advertised U & Laughs. Rebooting the 360 will probably result in a different banner being displayed at the top of the Home screen. Mine is currently advertising The Grand Tour on Prime Video.
Changing the 360 remote batteries can factory reset the remote.
Are you sure the batteries have been inserted correctly?
How did you re-pair the remote? Did you use the correct 'Live TV' button? (the one on the right hand side directly below the red power/standby button)
It should work by holding down the 'Live TV' and '0' button together for around 10/15 seconds. The Standby button should then start to flash followed by an onscreen message displaying 'Pairing successful - this remote will only work with this Virgin 360 box'.
You can also try the following:-
Put the box into 'Pairing Mode' by pressing the Standby/On button on the front of the 360 box for 10 seconds. Then using the remote control, press and hold the 'LIve TV' button and the '0' button together for 10/15 seconds. And fingers crossed hopefully a message should appear on the screen confirming that pairing was successful.
